Histomorphologic Effect of Castration on the Prostate Gland in Albino Wistar Rat

10 Albino Wister rats of about the same post-pubertal age, size and weight were used in this study. 7 of them were castrated and sacrificed in succession of four days interval to observe the effects of castration on the prostate gland. The other 3 served as the control. Paraffin wax sections were made, stained with Weiggert's Haematoxylin and Van Gieson's stain and studied under the light microscope. There was rapid loss of stereocilia, secretory granules and rapid reduction in height from Pseudostratified columnar epithelium to simple cuboidal cells. The interacinar tissue increased with reduction in size and diameter of acini. The nuclei became pyknotic. These go to show the dependence of the prostate gland on functional testes.

Key Words: Accessory Reproductive, Castration, Acini