Effects of Sesame Oil on the Liver of Adult Male Wistar Rat following Permethrin Exposure

The liver performs many vital functions to eliminate toxins and harmful substances from the body. Hepatotoxic agents can react with basic cellular components and consequently induce almost all types of liver lesions. This study aimed to investigate the possible hepatoprotective role of sesame oil against permethrin-induced hepatotoxicity in adult male Wistar rats from the histological and biochemical perspectives. In this study, forty adult male Wistar rats were used. They were grouped into four groups: the control group, the permethrin-treated group, which received feeds mixed with feed (1000 mg/kg permethrin), the sesame oil group, which received (5 ml/kg body wt), and the permethrin + sesame oil group. This treatment was done for 4 weeks, after which the rats were euthanized, the liver harvested, weighed, and either homogenized for biochemical studies or fixed in 10% formalin for histological analysis. The findings revealed notable microarchitectural changes in permethrin-treated animals, elevated liver enzymes, and depletion of oxidative markers. These changes were mitigated by sesame oil supplementation to a good extent. The study suggests that sesame oil supplementation has hepatoprotective effects against permethrin-induced hepatotoxicity.

Key Words: permethrin, sesame oil, hepatotoxicity, liver function, oxidative stress