Modulatory role of resveratrol on some biomarkers of oxidative stress and inflammation in diabetic nephropathy in Wistar rats

Diabetic nephropathy (DN) is a chronic debilitating microvascular complication of diabetes, and often leads to end-stage renal disease, a common cause of morbidity and mortality with high burden worldwide. Both oxidative stress and chronic inflammation had been implicated in the pathogenesis of DN. Resveratrol is a natural polyphenolic antioxidant with several beneficial effects in medicine due to its antioxidant, antidiabetic, anti-inflammatory, anticancer, neuroprotective among other properties. This study aimed to investigate the modulatory role of resveratrol in experimentally-induced diabetic nephropathy. Ethical approval was obtained from the institution’s Ethics Committee for Research Animal Care and Use. Twenty male Wistar rats were randomly assigned into five groups (n=4): normal control; normoglycemic + 1ml/kg carboxymethylcellulose (CMC); diabetic control; diabetic + 100mg/kg resveratrol; and diabetic + 1mg/kg lisinorpril. Twelve weeks after the induction and treatment, the animals were humanely sacrificed. Serum was collected for biochemical analysis. Values at P

Key Words: anti-inflammatory; anti-oxidant; diabetic nephropathy; oxidative stress; resveratrol.