Evaluation of Ogogoro-Induced Testicular Toxicity in Adult Male Wistar rats

Alcohol has been implicated in the aetiology of male infertility. Ogogoro, a locally brewed alcohol, is processed by distilling fermented sap of Raphia palms (Raphia hookeri) or coconut palm (cocus nucifera). The aim of this study was to evaluate Ogogoro induced testicular toxicity in adult male Wistar rats. Twenty (20) adult male Wistar rats were assigned into four groups (n=5) each. Group I (control) was administered with normal saline 1ml/kg, groups II-IV: Ogogoro 3.5ml/kg, 7ml/kg, and 14ml/kg respectively orally for eight weeks. Following animal sacrifice, blood samples, seminal fluid and testes were used for assay of reproductive hormones, seminal analysis, and testicular histology and oxidative stress biomarkers respectively. Serum testosterone and luteinizing hormone (LH) in groups III and IV were significantly (p

Key Words: Ogogoro, Testicular toxicity, Reproduction, Oxidative stress, lipid peroxidation