The Mitigating Effects of Sour Sop (Annona Muricata) Extract and Aloe Vera (Aloe Barbadenis Miller) Gel on Aluminium-Induced Hepatotoxicity in Adult Wistar Rats

Annona muricata and Aloe barbadenis miller are multipurpose plants of great economic value, identified to contain different plant phytochemical and biological activities The aim is to study the mitigating effect of Annona muricata extract and aloe barbadenis miller gel on an aluminum induced hepatotoxicity on the Liver of an adult Wistar rat with the objectives on histology and Liver function enzymes. Twenty-five Wistar rats ranged (100-150g) were used, divided into five groups, with five rats in each group. In the course of this study twenty-five rats (100-150g) were divided into five groups and used, with five rats in each group. Group A: (control): received rats pellet and water. Group B: were given 100mg/kg/d of AlCl3. Group C: received 100mg/kg/d of AlCl3 and 3ml/kg/d of sour-sop. Group D: given 100mg/kg/d of AlCl3 and 3ml/kg/d of aloe vera. Group E: Received 100mg/kg/d of AlCl3 with 3ml/kg/d of sour-sop and 3ml/kg/d of aloe vera. The rats were weighed and sacrificed twenty-four hours after the last administration sedated with diethyl-ether and livers were autopsied. The histological observations revealed loss of normal liver architecture with hepatocyte that attained different shapes and dilated central vein in the aluminium group when compared with control group. However, treatment with annona muricata and aloe barbadenis miller attenuates the effect of AlCl . In liver function enzyme test AlCl administration caused a significant increase in 3 3 serum total protein (TP), serum level of serum glutamic pyruvic transaminase (SGPT) and Alkaline phosphatase (ALP). Results showed that AlCl caused hepatotoxicity while significant decrease occurred in Serum glutamic 3 pyruvic transaminase and Alkaline phosphatase level in annona muricata -treated rats (p<0.05). Animals treated with Aluminium along with annona muricata as well as aloe barbadensis miller showed recovery of liver tissue structure and improved hepatic morphology. Conclusively, the use of annona muricata as well as aloe barbadensis miller has shown to be effective in mitigating aluminium-induced hepatic toxicity, therefore annona muricata and aloe barbadensis miller mitigates hepatotoxic effect AlCl administration.

Key Words: Liver, annona muricata, Hepotoxicity, aloe barbadenis miller, Aluminum Chloride