Effects of Rauwolfia vomitoria on the Haematological Indices and Hippocampal Histology of Wistar Rats

Rauwoifia vomitoria (Rv) has been reported to cause neurodegeneration in the cerebral cortex and cerebellum of experimental Wistar rats. Here we report the effect of varying concentrations ofRv on the haematological indices, hippocampal histology and immunohistochemistry ofWistar rats. Twenty (20) rats randomized into four groups of five rats received 20% of tween 80 1 ml (control) and Rv 100 mg, 200 mg and 300 mg per kilogram body weight of rats respectively (treatment groups) for fourteen days via orogavage. Results show that MCV was significantly (p

Key Words: Rauwoifia vomitoria, Haematology, Hippocampal distortions, Astrogliosis