Hippocampal Immunohistopathological and Blood Morphological Effects of Nauclea latifolia Extract and Artemether-Lumenfantrine in Suppressive Malaria Mice Model
The effect of ethanolic leave extract of Nauclea latifolia and Artemether-Lumfantrine was investigated in a suppressive model of malaria on the hippocampus of Swiss albino mice. Mice were infected intraperitoneally with P berghei 1 x 107 parasites, and then treated within an hour with Nacl 0.9% IOml/kg for control; and 5 mg Artemether-Lumefantrine per kg body weight of the mice for test 3 days. Organosomatic index, thick blood smear, parasite density, hippocampal histomorphology and immunolabeling of glial fibrillary acidic protein were assessed. Result show the organosomatic index was not statistically significant (p>0.05) when treated groups were compared with control; the parasite density decreased significantly (p
Key Words: Nauclea latifolia, Artemether-Lumefantrine, Plasmodium berghei, Gliosis